Gallbladder Secretion

Electrogenic bicarbonate secretion by prairie dog gallbladder.

Pathological rates of gallbladder salt and water transport may promote the formation of cholesterol gallstones. Because prairie dogs are widely used as a model of this event, we characterized gallbladder ion transport in animals fed control chow by using electrophysiology, ion substitution, pharmacology, isotopic fluxes, impedance analysis, and molecular biology. In contrast to the electroneutr...

Electrogenic bicarbonate secretion in mouse gallbladder.

Mouse gallbladders (4 mm2) were investigated using the short-circuit current ( I sc) technique. Responses of 50 μA/cm2 were obtained in response to forskolin and agents that stimulated the adenylate cyclase system (IBMX and dibutyryl-cAMP). The calcium ionophore ionomycin increased I sc to 30% of the forskolin-stimulated increase. The forskolin-dependent current was inhibited 40% by acetazolami...

Leptin regulates gallbladder genes related to absorption and secretion.

Dysregulation of gallbladder ion and water absorption and/or secretion has been linked to cholesterol crystal and gallstone formation. We have recently demonstrated that obese, leptin-deficient (Lep(ob)) mice have enlarged gallbladder volumes and decreased gallbladder contractility and that leptin administration to these mice normalizes gallbladder function. However, the effect of leptin on gal...

Gallbladder Volume Indicated for Gallbladder Dysmotility

Bicarbonate secretion in the murine gallbladder--lessons for the treatment of cystic fibrosis.

The epithelium lining the gallbladder of mammalian species has absorptive and secretory functions. An important function is the secretion of a bicarbonate rich fluid that helps neutralise stomach acid and provides an appropriate environment for intestinal enzymes. In cystic fibrosis (CF) this secretory function is lost. This study concerns the bicarbonate secreting activity of murine gallbladde...